Surgical Pathology 2017-06-08T22:29:08+00:00

Surgical Pathology

TOPA Diagnostics can process any specimen, including but not limited to:

Surgical Pathology
Breast core biopsy
Breast excisional biopsy
Skin/nipple biopsy
Lymph node biopsy
Lumpectomy
Mastectomy
Full range of immunochemistry for diagnostic needs:
Immunochemistry testing for predictive/prognostic markers (ER, PR, HER2/neu,   Ki-67, p53) on all malignancies using CAP guidelines for testing and reporting

Cytology
Breast Fine-Needle Aspiration
Nipple Discharge
Cyst Fluid
Lymph node FNA
Body fluids

Molecular
HER2 Testing by Immunohistochemistry and FISH on all malignancies
Other prognostics tests at the physician’s request

TOPA Diagnostics can process any specimen, including but not limited to:

Surgical Pathology
Skin biopsy
Soft tissue biopsy
Skin excision
Soft tissue excision
Immunohistochemistry for diagnosis and prognosis
Special stains for microorganisms

Cytology
Fluid cytology
Fine needle aspiration

Molecular Testing
BRAF testing on all metastatic melanoma cases
Melanoma FISH available

Send Out Testing
Cultures for microbiology

TOPA Diagnostics can process any specimen, including but not limited to:

Surgical Pathology
Skin biopsy
Soft tissue biopsy
Skin excision
Soft tissue excision
Thyroid FNA
Thyroid biopsy
Thyroidectomy
Parathyroidectomy
Tonsil biopsy
Tonsillectomy and adenoidectomy
Tongue biopsy
Palate biopsy
Parotid gland biopsy and parotidectomy
Lymph node core biopsy and excisional biopsy
Immunohistochemistry for diagnosis and prognosis
Testing for HPV on all ear, nose and throat malignancies (with p16 immunohistochemistry)
Special stains for microorganisms

Cytology
Fluid cytology
Fine needle aspiration (including thyroids and lymph nodes)

Molecular Testing
BRAF testing on all metastatic melanoma cases
Melanoma FISH available
Afirma® by Veracyte for thyroid FNA
ThyraMir™ & ThyGenX® by Interpace

Send Out Testing
Cultures for microbiology
Needle washings for thyroglobulin and parathyroid hormone testing

TOPA Diagnostics can process any specimen, including but not limited to:

Surgical Pathology
Esophageal Biopsy
Gastric Biopsy
Duodenal Biopsy
Terminal ileum Biopsy
Colorectal Biopsy
Anal Biopsy
Liver Biopsy
Pancreatic Biopsy
Lymph Node Biopsy
Full range of immunohistochemistry for diagnostic and prognostic testing: Special Stains for Helicobacter, fungus, and intestinal metaplasia routinely performed
Microsatellite Instability Testing on all new colorectal carcinomas
Her2 Testing on all gastric carcinomas

Cytology
Esophageal brushing
Endoscopic ultrasound guided (EUS) FNA and biopsy of pancreas

Molecular Testing
KRAS and BRAF PCR testing on metastatic colorectal cancers
Her2 FISH testing on all gastric carcinomas
FISH testing for Barrett’s esophagus
KIT/PDGFRA reflex profile on GIST tumors

Rapid Molecular Microbiology
(Results available same day or the following morning)
Biofire FilmArray GI Panel (more info)
Tests for 22 pathogens that commonly cause infections and diarrhea; PCR technology allows better sensitivity and specificity than culture

Patients can send the specimen to TOPA through pre-paid FedEx, Courier pick-up at the physician’s office, patient service centers (depending on their location), or drop off at TOPA’s Main Office. Please see instructional videos for details.

C. difficile (more info)
Tests for C. difficile and the hypervirulent strain of C. difficile, referred to as the BI/NAP1/027

Send Out Testing
Cultures for microbiology

TOPA Diagnostics can process any specimen, including but not limited to:

Surgical Pathology
Bone marrow aspiration and core biopsy
Lymph node biopsy
Lymph node excisional biopsy
Splenectomy
Skin Biopsy
Soft tissue/bone biopsy/excision
Solid tumor biopsy/excision
Full range of immunohistochemical stains for diagnosis and prognosis
Full range of special stains for microorganisms

Cytology
Bone marrow aspiration smears
Peripheral blood smears
Lymph node fine needle aspirations
Fine needle aspirations
Cyst fluid
Body fluid

Molecular/Ancillary/Prognostic Testing
FISH for myelodysplasia, lymphoma, leukemia, myeloma
Flow cytometry on peripheral blood
Flow cytometry on bone marrow aspirations
Cytogenetics on all bone marrow cases
EGFR, ALK, Ros1 testing on all lung adenocarcinomas
LYNCH Syndrome/Microsatellite instability testing onall colorectal cancers
RAS testing on all metastatic colorectal cancers
BRAF testing on all metastatic melanoma cases
her2, ER, PR, Ki-67, p53 on all breast carcinoma cases
her2 testing on all gastric cancers
p16 testing for HPV on all head and neck squamous cell carcinomas
Next Generation Sequencing
Microbiology cultures (complimentary send out program)

TOPA Diagnostics can process any specimen, including but not limited to:

Surgical Pathology
Cervical biopsy
Endocervical curettage
Endometrial biopsy (including evaluation for endometritis and endometrial dating)
Endometrial curettage
Vulvar biopsy
Skin biopsy
Breast biopsy
Products of conception (including cytogenetics)

Cytology
Pap smear
Nipple Discharge
Urine cytology
Fine Needle Aspirations

Molecular Testing
All tests are performed using FDA Approved molecular technologies
HPV testing of high-risk strains and genotyping of 16 * 18
Chlamydia
Gonorrhea
Affirm Tests (Candida, Gardnerella, Trichomonas)
Pertussis
Group A Strep
Influenza (Flu A, B, & H1N1-2009 Strain)
GI Rapid Molecular Microbiology Panel
C. Difficile Only
Respiratory Pathogen Panel

Other
Cytogenetics for chromosomal analysis of products of conception
IUD for microbiology cultures
Microbiology cultures

TOPA Diagnostics can process any specimen, including but not limited to:

Surgical Pathology
Nail
Skin biopsies and excisions
Soft tissue biopsies and excisions
Bone biopsies and excisions

Cytology
Fine Needle Aspiration
Crystal Analysis for gout and pseudogout

Microbiology
Mycology
• PAS stain for onychomycosis
• Classification of fungal organisms
• Fungal Cultures
Bacteriology
• Bacterial Cultures
• Gram Stains

TOPA Diagnostics can process any biopsy including but not limited to:

Surgical Pathology
Prostate biopsy
Prostate TURP
Prostatectomy
Bladder Biopsy
Bladder TURBT
Cystectomy
Kidney Biopsy
Nephrectomy
Testis Biopsy
Orchiectomy

Cytology
Urine Cytology
Ureter/Renal Pelvis Washing
Semen Analysis for Vasectomy

Molecular Testing
Urine FISH
Gonorrhea from urine
Chlamydia from urine

Send out Capabilities
Stone Analysis
Microbiology Cultures
PCA3
Molecular prognostic tests at your request

Results delivered in 24 to 48 hours.